{"id":801,"date":"2019-04-10T22:46:50","date_gmt":"2019-04-11T03:46:50","guid":{"rendered":"https:\/\/www.ozonoterapia-peru.org\/?page_id=801"},"modified":"2019-11-15T01:37:22","modified_gmt":"2019-11-15T06:37:22","slug":"estudios-cientificos","status":"publish","type":"page","link":"https:\/\/www.ozonoterapia-peru.org\/?page_id=801","title":{"rendered":"Estudios cient\u00edficos"},"content":{"rendered":"<div class=\"pmid-refs\"><ul><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42404033\/\" target=\"_blank\" rel=\"noopener noreferrer\">A randomized controlled trial comparing transforaminal injections of Platelet-rich plasma versus steroid for lumbar herniated disc.<\/a><br><small><strong>Authors:<\/strong> Sonkar T, Yadav V, Singh S<\/small><br><small><strong>Published:<\/strong> 2026 Oct<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42023259\/\" target=\"_blank\" rel=\"noopener noreferrer\">Protocol for a pragmatic randomized controlled trial evaluating a care pathway incorporating ultrasound-guided platelet-rich plasma injection plus physiotherapy versus physiotherapy alone in patients with L5\/S1 lumbar disc herniation.<\/a><br><small><strong>Authors:<\/strong> Islam R, Udoy MH, Islam MZ, Sayeed MA, Kabir F, Hossain MZ, Jahan S, Rahman E, Hossain MA, Hossain KMA<\/small><br><small><strong>Published:<\/strong> 2026 Jun<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41487424\/\" target=\"_blank\" rel=\"noopener noreferrer\">Recent advances and evolving strategies in the treatment of lumbar disc herniation.<\/a><br><small><strong>Authors:<\/strong> Tong Y, Yu L, Luo K, Yan X, Chen M, Wang L<\/small><br><small><strong>Published:<\/strong> 2025<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41480501\/\" target=\"_blank\" rel=\"noopener noreferrer\">Efficacy of intradiscal autologous platelet-rich plasma injection in chronic lumbar disc prolapse: A quasi-experimental study.<\/a><br><small><strong>Authors:<\/strong> Mounisamy P, Dwajan A, Sahoo D, Jeyaraman N, Muthu S, Ramasubramanian S, Jeyaraman M<\/small><br><small><strong>Published:<\/strong> 2025 Dec 18<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40969942\/\" target=\"_blank\" rel=\"noopener noreferrer\">Efficacy of platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis.<\/a><br><small><strong>Authors:<\/strong> Zhang Y, Ju J, Wu J<\/small><br><small><strong>Published:<\/strong> 2025<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40713810\/\" target=\"_blank\" rel=\"noopener noreferrer\">Application and mechanism of percutaneous puncture disc platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis.<\/a><br><small><strong>Authors:<\/strong> Xie X, Peng Y, Liu G, Cao Q<\/small><br><small><strong>Published:<\/strong> 2025 Jul 25<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40708286\/\" target=\"_blank\" rel=\"noopener noreferrer\">Comparison of full endoscopic lumbar discectomy combined with and without platelet-rich plasma injections for lumbar disc herniation: a meta-analysis.<\/a><br><small><strong>Authors:<\/strong> Lu L, Xiao K, He LR, Chen RS, Zeng TH, Lin GX<\/small><br><small><strong>Published:<\/strong> 2025 Oct<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40496640\/\" target=\"_blank\" rel=\"noopener noreferrer\">The clinical efficacy of percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis.<\/a><br><small><strong>Authors:<\/strong> Song H, Zhang Y<\/small><br><small><strong>Published:<\/strong> 2025<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40434733\/\" target=\"_blank\" rel=\"noopener noreferrer\">Minimally invasive surgery for lumbar disc herniation: a meta-analysis of efficacy and safety.<\/a><br><small><strong>Authors:<\/strong> Liu S, Zhang X, Xiong Y, He H<\/small><br><small><strong>Published:<\/strong> 2025 Aug 1<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40128857\/\" target=\"_blank\" rel=\"noopener noreferrer\">Therapeutic interventions of platelet-rich plasma versus corticosteroid injections for lumbar radicular pain: a systematic review and meta-analysis.<\/a><br><small><strong>Authors:<\/strong> Wang X, Zhang Y<\/small><br><small><strong>Published:<\/strong> 2025 Mar 25<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40004728\/\" target=\"_blank\" rel=\"noopener noreferrer\">Review of Recent Treatment Strategies for Lumbar Disc Herniation (LDH) Focusing on Nonsurgical and Regenerative Therapies.<\/a><br><small><strong>Authors:<\/strong> Lee JS, Lee SB, Kang KY, Oh SH, Chae DS<\/small><br><small><strong>Published:<\/strong> 2025 Feb 12<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39968415\/\" target=\"_blank\" rel=\"noopener noreferrer\">Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials.<\/a><br><small><strong>Authors:<\/strong> Muthu S, Viswanathan VK, Gangadaran P<\/small><br><small><strong>Published:<\/strong> 2025<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39621982\/\" target=\"_blank\" rel=\"noopener noreferrer\">Long-term Investigation of Annulargrams and Intra-annular Fibrin to Treat Chronic Discogenic Low Back Pain and Radiculopathy: 1-, 2-, and 3-Year Outcome Comparisons of Patients with and without Prior Surgery.<\/a><br><small><strong>Authors:<\/strong> Pauza K, Boachie-Adjei K, Nguyen JT, Hussey Iv F, Sutton J, Serwaa-Sarfo A, Ercole PM, Wright C, Murrell WD<\/small><br><small><strong>Published:<\/strong> 2024 Nov<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39402583\/\" target=\"_blank\" rel=\"noopener noreferrer\">Evaluating the impact of platelet-rich plasma injection in spinal endoscopic nucleotomy on MRI pfirrmann grading and clinical outcomes in lumbar disc herniation.<\/a><br><small><strong>Authors:<\/strong> Qi H, Zhou Z, Li G, Huang Y, Chen S, Liu B<\/small><br><small><strong>Published:<\/strong> 2024 Oct 15<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38658984\/\" target=\"_blank\" rel=\"noopener noreferrer\">Percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: analysis of clinical and imaging outcomes.<\/a><br><small><strong>Authors:<\/strong> Li T, Du W, Ding Z, Liu J, Ding Y<\/small><br><small><strong>Published:<\/strong> 2024 Apr 24<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38433432\/\" target=\"_blank\" rel=\"noopener noreferrer\">Lumbar Transforaminal Injection of Steroids versus Platelet-Rich Plasma for Prolapse Lumbar Intervertebral Disc with Radiculopathy: A Randomized Double-Blind Controlled Pilot Study.<\/a><br><small><strong>Authors:<\/strong> Gupta A, Chhabra HS, Singh V, Nagarjuna D<\/small><br><small><strong>Published:<\/strong> 2024 Feb<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38382454\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Bibliographic review of the efficacy of platelet-rich plasma treatment in lumbar disc herniation].<\/a><br><small><strong>Authors:<\/strong> Guerrero-Molina AL, Cruz-\u00c1lvarez MG, Tenopala-Villegas S<\/small><br><small><strong>Published:<\/strong> 2023 Sep-Oct<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37941067\/\" target=\"_blank\" rel=\"noopener noreferrer\">Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase.<\/a><br><small><strong>Authors:<\/strong> Hasegawa T, Akeda K, Yamada J, Kawaguchi K, Takegami N, Fujiwara T, Natsume T, Ide K, Matsuyama Y, Sudo A<\/small><br><small><strong>Published:<\/strong> 2023 Nov 8<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37605261\/\" target=\"_blank\" rel=\"noopener noreferrer\">Combination of percutaneous endoscopic lumbar discectomy and platelet-rich plasma hydrogel injection for the treatment of lumbar disc herniation.<\/a><br><small><strong>Authors:<\/strong> Zhang L, Zhang C, Song D, Chen G, Liu L<\/small><br><small><strong>Published:<\/strong> 2023 Aug 21<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37118707\/\" target=\"_blank\" rel=\"noopener noreferrer\">&quot;Platelet-Rich Plasma&quot; epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial.<\/a><br><small><strong>Authors:<\/strong> Wongjarupong A, Pairuchvej S, Laohapornsvan P, Kotheeranurak V, Jitpakdee K, Yeekian C, Chanplakorn P<\/small><br><small><strong>Published:<\/strong> 2023 Apr 28<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36899464\/\" target=\"_blank\" rel=\"noopener noreferrer\">Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma\/Ferulic Acid Hydrogel.<\/a><br><small><strong>Authors:<\/strong> Chai Q, Zhang B, Da Y, Wang W, Gao Y, Yao M, Zhu H, Yang X, Zhu Y<\/small><br><small><strong>Published:<\/strong> 2023 Dec<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36676735\/\" target=\"_blank\" rel=\"noopener noreferrer\">Autologous Platelet-Rich Plasma Administration on the Intervertebral Disc in Low Back Pain Patients with Modic Type 1 Change: Report of Two Cases.<\/a><br><small><strong>Authors:<\/strong> Kawabata S, Hachiya K, Nagai S, Takeda H, Rashid MZM, Ikeda D, Kawano Y, Kaneko S, Ohno Y, Fujita N<\/small><br><small><strong>Published:<\/strong> 2023 Jan 5<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36475103\/\" target=\"_blank\" rel=\"noopener noreferrer\">The retrospective analysis of platelet-rich plasma and corticosteroid injection under epiduroscopic guidance for radiculopathy in operated or unoperated patients for lumbar disc herniation.<\/a><br><small><strong>Authors:<\/strong> Demirci AY<\/small><br><small><strong>Published:<\/strong> 2022 Sep<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35637114\/\" target=\"_blank\" rel=\"noopener noreferrer\">Transforaminal injection of autologous platelet-rich plasma for lumbar disc herniation: A single-center prospective study in Vietnam.<\/a><br><small><strong>Authors:<\/strong> Le VT, Nguyen Dao LT, Nguyen AM<\/small><br><small><strong>Published:<\/strong> 2023 Jan<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35344055\/\" target=\"_blank\" rel=\"noopener noreferrer\">Clinical outcomes following intradiscal injections of higher-concentration platelet-rich plasma in patients with chronic lumbar discogenic pain.<\/a><br><small><strong>Authors:<\/strong> Lutz C, Cheng J, Prysak M, Zukofsky T, Rothman R, Lutz G<\/small><br><small><strong>Published:<\/strong> 2022 Jun<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35296040\/\" target=\"_blank\" rel=\"noopener noreferrer\">Transforaminal Endoscopic Lumbar Discectomy with versus without Platelet-Rich Plasma Injection for Lumbar Disc Herniation: A Prospective Cohort Study.<\/a><br><small><strong>Authors:<\/strong> Jiang Y, Zuo R, Yuan S, Li J, Liu C, Zhang J, Ma M, Li D, Hai Y<\/small><br><small><strong>Published:<\/strong> 2022<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34376494\/\" target=\"_blank\" rel=\"noopener noreferrer\">Risks of Intradiscal Orthobiologic Injections: A Review of the Literature and Case Series Presentation.<\/a><br><small><strong>Authors:<\/strong> Jerome MA, Lutz C, Lutz GE<\/small><br><small><strong>Published:<\/strong> 2021 Apr<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34352363\/\" target=\"_blank\" rel=\"noopener noreferrer\">The effectiveness of intradiscal biologic treatments for discogenic low back pain: a systematic review.<\/a><br><small><strong>Authors:<\/strong> Schneider BJ, Hunt C, Conger A, Qu W, Maus TP, Vorobeychik Y, Cheng J, Duszynski B, McCormick ZL<\/small><br><small><strong>Published:<\/strong> 2022 Feb<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34135954\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.<\/a><br><small><strong>Authors:<\/strong> Xu Z, Wu S, Li X, Liu C, Fan S, Ma C<\/small><br><small><strong>Published:<\/strong> 2021<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32869064\/\" target=\"_blank\" rel=\"noopener noreferrer\">Intradiscal Platelet-Rich Plasma Injection for Discogenic Low Back Pain and Correlation with Platelet Concentration: A Prospective Clinical Trial.<\/a><br><small><strong>Authors:<\/strong> Jain D, Goyal T, Verma N, Paswan AK, Dubey RK<\/small><br><small><strong>Published:<\/strong> 2020 Nov 1<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32093768\/\" target=\"_blank\" rel=\"noopener noreferrer\">Vertebral intraosseous plasma rich in growth factor (PRGF-Endoret) infiltrations as a novel strategy for the treatment of degenerative lesions of endplate in lumbar pathology: description of technique and case presentation.<\/a><br><small><strong>Authors:<\/strong> Kirchner F, Pinar A, Milani I, Prado R, Padilla S, Anitua E<\/small><br><small><strong>Published:<\/strong> 2020 Feb 24<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28546769\/\" target=\"_blank\" rel=\"noopener noreferrer\">Treatment of chronic low back pain - new approaches on the horizon.<\/a><br><small><strong>Authors:<\/strong> Knezevic NN, Mandalia S, Raasch J, Knezevic I, Candido KD<\/small><br><small><strong>Published:<\/strong> 2017<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27073034\/\" target=\"_blank\" rel=\"noopener noreferrer\">Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update.<\/a><br><small><strong>Authors:<\/strong> Monfett M, Harrison J, Boachie-Adjei K, Lutz G<\/small><br><small><strong>Published:<\/strong> 2016 Jun<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26314234\/\" target=\"_blank\" rel=\"noopener noreferrer\">Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study.<\/a><br><small><strong>Authors:<\/strong> Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, Harrison JR, Gribbin CK, LaSalle EE, Nguyen JT, Solomon JL, Lutz GE<\/small><br><small><strong>Published:<\/strong> 2016 Jan<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26147759\/\" target=\"_blank\" rel=\"noopener noreferrer\">The Effects of Platelet-Rich Plasma on Halting the Progression in Porcine Intervertebral Disc Degeneration.<\/a><br><small><strong>Authors:<\/strong> Cho H, Holt DC 3rd, Smith R, Kim SJ, Gardocki RJ, Hasty KA<\/small><br><small><strong>Published:<\/strong> 2016 Feb<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21627344\/\" target=\"_blank\" rel=\"noopener noreferrer\">Hot ortho-biologic topics at AAOS 2011\u2020: platelet-rich plasma and related growth factors generate excitement.<\/a><br><small><strong>Authors:<\/strong> Hoggatt J<\/small><br><small><strong>Published:<\/strong> 2011 Jun 1<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19646749\/\" target=\"_blank\" rel=\"noopener noreferrer\">Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma.<\/a><br><small><strong>Authors:<\/strong> Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP<\/small><br><small><strong>Published:<\/strong> 2009 Oct<\/small><\/li><li style=\"margin-bottom:15px;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17518588\/\" target=\"_blank\" rel=\"noopener noreferrer\">Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres.<\/a><br><small><strong>Authors:<\/strong> Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda K, Sakamoto H, Tabata Y, Kawata M, Kubo T<\/small><br><small><strong>Published:<\/strong> 2007 Jan<\/small><\/li><\/ul><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":48,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_joinchat":[],"footnotes":""},"class_list":["post-801","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/pages\/801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=801"}],"version-history":[{"count":2,"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/pages\/801\/revisions"}],"predecessor-version":[{"id":820,"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/pages\/801\/revisions\/820"}],"up":[{"embeddable":true,"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=\/wp\/v2\/pages\/48"}],"wp:attachment":[{"href":"https:\/\/www.ozonoterapia-peru.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}