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Estudios científicos

Estudios clinicos en pacientes con hernia discal tratados con ozono

  1. Latini, E, Nusca, SM, Curci, ER, Boaretto, D, Santoboni, F, Trischitta, D et al.. Intramuscular paravertebral oxygen-ozone therapy for chronic neck pain and low back pain: evaluation of 6-month clinical outcomes. Med Gas Res. 2024;14 (1):6-11. doi: 10.4103/2045-9912.374388. PubMed PMID:37721249 PubMed Central PMC10710283.
  2. Latini, E, Bonasia, G, Petroselli, L, Mazzola, M, Musa, F, Santoboni, F et al.. Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated Disc. Pain Physician. 2023;26 (4):E363-E373. . PubMed PMID:37535783 .
  3. Sumida, JM, Matera, JM, Hayashi, AM. Randomized single-blinded prospective comparison between ozone therapy and electroacupuncture for canine thoracolumbar disk disease. Res Vet Sci. 2023;161 :173-179. doi: 10.1016/j.rvsc.2023.06.019. PubMed PMID:37413829 .
  4. Somma, F, Negro, A, Tortora, M, Gemini, L, Pace, G, Fasano, F et al.. Sex life and low back pain: The impact of intradiscal ozone therapy in patients with herniated lumbar disc. Interv Neuroradiol. 2023; :15910199231183108. doi: 10.1177/15910199231183108. PubMed PMID:37321647 .
  5. Ghatge, SB, Shah, RP, Surya, N, Sankhala, S, Unadkat, CJ, Khan, GM et al.. Ozone disc nucleolysis in the management of herniated lumbar intervertebral disc: A retrospective analysis. J Craniovertebr Junction Spine. 2023;14 (1):16-23. doi: 10.4103/jcvjs.jcvjs_141_22. PubMed PMID:37213581 PubMed Central PMC10198213.
  6. Grangeat, AM, Erario, MLA. The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment. Int J Mol Sci. 2023;24 (7):. doi: 10.3390/ijms24076538. PubMed PMID:37047511 PubMed Central PMC10095297.
  7. Zhang, W, Wang, Z, Yin, J, Bai, Y, Qiu, F, Zhang, H et al.. Clinical treatment of lumbar disc herniation. Ann Ital Chir. 2022;93 :457-462. . PubMed PMID:36155998 .
  8. Mungmunpuntipantip, R, Wiwanitkit, V. COVID-19, intradiscal ozone therapy and back pain: a correspondence. Radiol Med. 2022;127 (10):1179. doi: 10.1007/s11547-022-01544-y. PubMed PMID:36057928 PubMed Central PMC9440995.
  9. Re, K, Gandhi, J, Liang, R, Patel, S, Joshi, G, Smith, NL et al.. Clinical utility of ozone therapy and hyperbaric oxygen therapy in degenerative disc disease. Med Gas Res. 2023;13 (1):1-6. doi: 10.4103/2045-9912.351890. PubMed PMID:35946215 PubMed Central PMC9480354.
  10. Fathy, W, Hussein, M, Ibrahim, RE, Abdel-Aziz, MM, Adel, S, Soliman, SH et al.. Comparative effect of transforaminal injection of Magnesium sulphate versus Ozone on oxidative stress biomarkers in lumbar disc related radicular pain. BMC Anesthesiol. 2022;22 (1):254. doi: 10.1186/s12871-022-01789-0. PubMed PMID:35941548 PubMed Central PMC9358797.
  11. Bonetti, M, Lauritano, D, Ottaviani, GM, Fontana, A, Zambello, A, Della Gatta, L et al.. Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients. Int J Environ Res Public Health. 2022;19 (9):. doi: 10.3390/ijerph19095716. PubMed PMID:35565111 PubMed Central PMC9100908.
  12. Somma, F, Negro, A, D'Agostino, V, Piscitelli, V, Pace, G, Tortora, M et al.. COVID-19 and low back pain: previous infections lengthen recovery time after intradiscal ozone therapy in patients with herniated lumbar disc. Radiol Med. 2022;127 (6):673-680. doi: 10.1007/s11547-022-01500-w. PubMed PMID:35536526 PubMed Central PMC9088142.
  13. Salaria, AK, Dhatt, SS, Kumar, V, Neradi, D, Sodavarapu, P, Kumar, N et al.. Mycobacterium tuberculosis Infection of the Spine Secondary to Oxygen - Ozone Therapy for Prolapse Intervertebral Disc: A Scoping Review. J Orthop Case Rep. 2021;11 (6):23-26. doi: 10.13107/jocr.2021.v11.i06.2242. PubMed PMID:35437492 PubMed Central PMC9009488.
  14. Somma, F, Gatta, G, Negro, A, Tortora, M, Rea, G, Tamburrini, S et al.. Intradiscal ozone therapy: fluoroscopic guidance reduces operative time in comparison with CT guidance in patients with lumbar disc herniation. Radiol Med. 2022;127 (5):526-533. doi: 10.1007/s11547-022-01469-6. PubMed PMID:35290568 .
  15. Somma, F, D'Agostino, V, Negro, A, Piscitelli, V, Tamburrini, S, Sicignano, C et al.. Radiation exposure and clinical outcome in patients undergoing percutaneous intradiscal ozone therapy for disc herniation: Fluoroscopic versus conventional CT guidance. PLoS One. 2022;17 (3):e0264767. doi: 10.1371/journal.pone.0264767. PubMed PMID:35290390 PubMed Central PMC8923460.
  16. Kelekis, A, Bonaldi, G, Cianfoni, A, Filippiadis, D, Scarone, P, Bernucci, C et al.. Intradiscal oxygen-ozone chemonucleolysis versus microdiscectomy for lumbar disc herniation radiculopathy: a non-inferiority randomized control trial. Spine J. 2022;22 (6):895-909. doi: 10.1016/j.spinee.2021.11.017. PubMed PMID:34896609 .
  17. Krahulik, D, Vaverka, M, Hrabalek, L, Pohlodek, D, Jablonsky, J, Valosek, J et al.. Periradicular corticosteroid infiltration for radicular pain - comparison of Diprophos and Depomedrone and ozone effects. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023;167 (1):80-84. doi: 10.5507/bp.2021.061. PubMed PMID:34782796 .
  18. Sconza, C, Leonardi, G, Kon, E, Respizzi, S, Massazza, G, Marcacci, M et al.. Oxygen-ozone therapy for the treatment of low back pain: a systematic review of randomized controlled trials. Eur Rev Med Pharmacol Sci. 2021;25 (19):6034-6046. doi: 10.26355/eurrev_202110_26881. PubMed PMID:34661263 .
  19. Simon, C, Le Corroller, T, Pauly, V, Creze, M, Champsaur, P, Guenoun, D et al.. Intradiscal oxygen-ozone therapy for the treatment of symptomatic lumbar disc herniation: A preliminary study. J Neuroradiol. 2022;49 (2):180-186. doi: 10.1016/j.neurad.2021.09.004. PubMed PMID:34634298 .
  20. Erario, MLÁ, Croce, E, Moviglia Brandolino, MT, Moviglia, G, Grangeat, AM. Ozone as Modulator of Resorption and Inflammatory Response in Extruded Nucleus Pulposus Herniation. Revising Concepts. Int J Mol Sci. 2021;22 (18):. doi: 10.3390/ijms22189946. PubMed PMID:34576108 PubMed Central PMC8469341.
  21. Bruno, F, Carboni, N, Palumbo, P, Arrigoni, F, Varrassi, M, Izzo, A et al.. O2-O3 chemodiscolysis: How much, how long? Retrospective outcome evaluation of different treatment sessions in partially-responder patients. Interv Neuroradiol. 2022;28 (4):433-438. doi: 10.1177/15910199211039914. PubMed PMID:34516319 PubMed Central PMC9326869.
  22. Clavo, B, Robaina, F, Urrutia, G, Bisshopp, S, Ramallo, Y, Szolna, A et al.. Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial. Complement Ther Med. 2021;59 :102724. doi: 10.1016/j.ctim.2021.102724. PubMed PMID:33964405 .
  23. Sucuoğlu, H, Soydaş, N. Does paravertebral ozone injection have efficacy as an additional treatment for acute lumbar disc herniation? A randomized, double-blind, placebo-controlled study. J Back Musculoskelet Rehabil. 2021;34 (5):725-733. doi: 10.3233/BMR-200194. PubMed PMID:33843663 .
  24. Leoni, MLG, Caruso, A, Micheli, F. Factors Predicting Successful Outcome for Ozone Chemonucleolysis in Lumbar Disk Herniation. Pain Pract. 2021;21 (6):653-661. doi: 10.1111/papr.13006. PubMed PMID:33721371 .
  25. Sconza, C, Braghetto, G, Respizzi, S, Morenghi, E, Kon, E, Di Matteo, B et al.. Ultrasound-guided periradicular oxygen-ozone injections as a treatment option for low back pain associated with sciatica. Int Orthop. 2021;45 (5):1239-1246. doi: 10.1007/s00264-021-04975-w. PubMed PMID:33629173 .
  26. Li, J, Liang, S, Xie, W, Luo, J, Tang, J, Liu, L et al.. Symptomatic postoperative discal pseudocyst following percutaneous endoscopic lumbar discectomy: A case report and review of the literature. Medicine (Baltimore). 2021;100 (3):e24026. doi: 10.1097/MD.0000000000024026. PubMed PMID:33545999 PubMed Central PMC7837847.
  27. Akkawi, I. Ozone therapy for musculoskeletal disorders Current concepts. Acta Biomed. 2020;91 (4):e2020191. doi: 10.23750/abm.v91i4.8979. PubMed PMID:33525293 PubMed Central PMC7927499.
  28. Yalçın, Ü. Paravertebral intramuscular ozone therapy in lumbar disc hernia: A comprehensive retrospective study. J Back Musculoskelet Rehabil. 2021;34 (4):597-604. doi: 10.3233/BMR-200129. PubMed PMID:33523038 .
  29. Yang, Y, Liang, XG, Li, PQ, Li, GB, Guan, K. Clinical efficacy of targeted injection of drugs in combination with ozone in treatment of lumbar disc protrusion. Pak J Pharm Sci. 2020;33 (3(Special)):1373-1376. . PubMed PMID:33361025 .
  30. Alexandre, A, Zalaffi, A. Electromyographic analysis of the results given by lumbar discal herniation treatment with intradiscal oxygen-ozone gas mixture injection. J Biol Regul Homeost Agents. 2020;34 (4 Suppl. 1):57-61. SPECIAL ISSUE: OZONE THERAPY. . PubMed PMID:33176418 .
  31. Martinelli, M, Giovannangeli, F, Venditto, T, Travagli, V. The use of oxygen ozone therapy in the treatment of cervicobrachial pain: case series study. J Biol Regul Homeost Agents. 2020;34 (4 Suppl. 1):47-55. SPECIAL ISSUE: OZONE THERAPY. . PubMed PMID:33176417 .
  32. Bonetti, M, Zambello, A, Princiotta, C, Pellicanò, G, Della Gatta, L, Muto, M et al.. Non-discogenic low back pain treated with oxygen-ozone: outcome in selected applications. J Biol Regul Homeost Agents. 2020;34 (4 Suppl. 1):21-30. SPECIAL ISSUE: OZONE THERAPY. . PubMed PMID:33176414 .
  33. Della Gatta, L, Guarnieri, G, Ambrosanio, G, Capobianco, E, Muto, M. Clinical and imaging selection for CT guided - fluoroscopy 0203 disk treatment. J Biol Regul Homeost Agents. 2020;34 (4 Suppl. 1):15-19. SPECIAL ISSUE: OZONE THERAPY. . PubMed PMID:33176413 .
  34. Migliorini, F, Maffulli, N, Eschweiler, J, Bestch, M, Tingart, M, Baroncini, A et al.. Ozone injection therapy for intervertebral disc herniation. Br Med Bull. 2020;136 (1):88-106. doi: 10.1093/bmb/ldaa032. PubMed PMID:33128379 .
  35. Ercalik, T, Kilic, M. Efficacy of Intradiscal Ozone Therapy with or without Periforaminal Steroid Injection on Lumbar Disc Herniation: A Double-Blinded Controlled Study. Pain Physician. 2020;23 (5):477-484. . PubMed PMID:32967390 .
  36. Barbosa, LT, Rodrigues, CFS, Andrade, RR, Barbosa, FT. The effectiveness of percutaneous injections of ozonotherapy in low back pain. Rev Assoc Med Bras (1992). 2020;66 (8):1146-1151. doi: 10.1590/1806-9282.66.8.1146. PubMed PMID:32935812 .
  37. Nociti, V, Picarelli, C, Losavio, FA, Reale, G, Giuliano, G, Della Marca, G et al.. Posterior Reversible Encephalopathy Syndrome After Intramuscular Oxygen-Ozone Therapy. Can J Neurol Sci. 2020;47 (3):416-418. doi: 10.1017/cjn.2020.35. PubMed PMID:32077386 .
  38. de Sire, A, Baricich, A, Minetto, MA, Cisari, C, Invernizzi, M. Low back pain related to a sacral insufficiency fracture: role of paravertebral oxygen-ozone therapy in a paradigmatic case of nociplastic pain. Funct Neurol. 2019;34 (2):119-122. . PubMed PMID:31556392 .
  39. Andreini, I, Arrigucci, U, Monti, L, Bellini, M, Battisti, C, Federico, A et al.. A case of pneumocephalus as complication of ozone therapy: diagnosis and treatment. Neurol Sci. 2020;41 (2):481-483. doi: 10.1007/s10072-019-04062-4. PubMed PMID:31478149 .
  40. Chirchiglia, D, Chirchiglia, P, Stroscio, C, Volpentesta, G, Lavano, A. Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain. J Neurol Surg A Cent Eur Neurosurg. 2019;80 (6):503-506. doi: 10.1055/s-0039-1685197. PubMed PMID:31430795 .
  41. Özcan, Ç, Polat, Ö, Çelik, H, Uçar, BY. The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain. Pain Pract. 2019;19 (8):821-825. doi: 10.1111/papr.12812. PubMed PMID:31228871 .
  42. Bhatia, A, Munk, P, Lee, D, Elias, G, Murphy, K. Percutaneous Ozone Treatment for Herniated Lumbar Discs: 1-Year Follow-up of a Multicenter Pilot Study of a Handheld Disposable Ozone-Generating Device. J Vasc Interv Radiol. 2019;30 (5):752-760. doi: 10.1016/j.jvir.2018.09.037. PubMed PMID:30922796 .
  43. Di Mauro, R, Cantarella, G, Bernardini, R, Di Rosa, M, Barbagallo, I, Distefano, A et al.. The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases. Int J Mol Sci. 2019;20 (3):. doi: 10.3390/ijms20030634. PubMed PMID:30717203 PubMed Central PMC6387239.
  44. Wang, J, Wu, M, Lin, X, Li, Y, Fu, Z. Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats. Pain Res Manag. 2018;2018 :5192814. doi: 10.1155/2018/5192814. PubMed PMID:30651902 PubMed Central PMC6311849.
  45. Costa, T, Linhares, D, Ribeiro da Silva, M, Neves, N. Ozone therapy for low back pain. A systematic review. Acta Reumatol Port. 2018;43 (3):172-181. . PubMed PMID:30414366 .
  46. Seyam, O, Smith, NL, Reid, I, Gandhi, J, Jiang, W, Khan, SA et al.. Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res. 2018;8 (3):103-110. doi: 10.4103/2045-9912.241075. PubMed PMID:30319765 PubMed Central PMC6178642.
  47. Hosseini, B, Taheri, M, Sheibani, K. Comparing the results of intradiscal ozone injection to treat different types of intervertebral disc herniation based on MSU classification. Interv Neuroradiol. 2019;25 (1):111-116. doi: 10.1177/1591019918800458. PubMed PMID:30227808 PubMed Central PMC6378534.
  48. Ezeldin, M, Leonardi, M, Princiotta, C, Dall'olio, M, Tharwat, M, Zaki, M et al.. Percutaneous ozone nucleolysis for lumbar disc herniation. Neuroradiology. 2018;60 (11):1231-1241. doi: 10.1007/s00234-018-2083-4. PubMed PMID:30206674 PubMed Central PMC6208962.
  49. Beyaz, SG, Sayhan, H. Six-Month Results of Cervical Intradiscal Oxygen-Ozone Mixture Therapy on Patients with Neck Pain: Preliminary Findings. Pain Physician. 2018;21 (4):E449-E456. . PubMed PMID:30045611 .
  50. Ozcan, S, Muz, A, Yildiz Altun, A, Onal, SA. Intradiscal ozone therapy for lumbar disc herniation. Cell Mol Biol (Noisy-le-grand). 2018;64 (5):52-55. . PubMed PMID:29729693 .
  51. Biazzo, A, Corriero, AS, Confalonieri, N. Intramuscular oxygen-ozone therapy in the treatment of low back pain. Acta Biomed. 2018;89 (1):41-46. doi: 10.23750/abm.v89i1.5315. PubMed PMID:29633741 PubMed Central PMC6357609.
  52. Niu, T, Lv, C, Yi, G, Tang, H, Gong, C, Niu, S et al.. Therapeutic Effect of Medical Ozone on Lumbar Disc Herniation. Med Sci Monit. 2018;24 :1962-1969. doi: 10.12659/msm.903243. PubMed PMID:29611536 PubMed Central PMC5896688.
  53. Yang, CS, Zhang, LJ, Sun, ZH, Yang, L, Shi, FD. Acute prevertebral abscess secondary to intradiscal oxygen-ozone chemonucleolysis for treatment of a cervical disc herniation. J Int Med Res. 2018;46 (6):2461-2465. doi: 10.1177/0300060518764186. PubMed PMID:29584512 PubMed Central PMC6023037.
  54. Elawamy, A, Kamel, EZ, Hassanien, M, Wahba, OM, Amin, SE. Implication of Two Different Doses of Intradiscal Ozone-Oxygen Injection upon the Pain Alleviation in Patients with Low Back Pain: A Randomized, Single-Blind Study. Pain Physician. 2018;21 (1):E25-E31. . PubMed PMID:29357333 .
  55. Wang, H, Zhou, Y, Jiang, Z. Ozone injection with or without percutaneous microdiscectomy for treatment of cervical disc herniation. Technol Health Care. 2018;26 (2):319-327. doi: 10.3233/THC-170956. PubMed PMID:29332056 .
  56. Ghatge, S, Modi, PD, Modi, DB. Clinical and Radiological Improvement Following Ozone Disc Nucleolysis: A Case Report. Cureus. 2017;9 (4):e1162. doi: 10.7759/cureus.1162. PubMed PMID:28507834 PubMed Central PMC5429154.
  57. Bruno, F, Smaldone, F, Varrassi, M, Arrigoni, F, Barile, A, Di Cesare, E et al.. MRI findings in lumbar spine following O2-O3 chemiodiscolysis: A long-term follow-up. Interv Neuroradiol. 2017;23 (4):444-450. doi: 10.1177/1591019917703784. PubMed PMID:28485657 PubMed Central PMC5684903.
  58. Giurazza, F, Guarnieri, G, Murphy, KJ, Muto, M. Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation. Can Assoc Radiol J. 2017;68 (2):171-177. doi: 10.1016/j.carj.2016.12.007. PubMed PMID:28438284 .
  59. Vaiano, AS, Valente, C, De Benedetti, G, Caramello, G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64 (12):944-946. doi: 10.4103/0301-4738.198858. PubMed PMID:28112142 PubMed Central PMC5322716.
  60. Andrés-Cano, P, Vela, T, Cano, C, García, G, Vera, JC, Andrés-García, JA et al.. Cervical Spondylodiscitis After Oxygen-Ozone Therapy for Treatment of a Cervical Disc Herniation: a Case Report and Review of the Literature. HSS J. 2016;12 (3):278-283. doi: 10.1007/s11420-016-9500-1. PubMed PMID:27703423 PubMed Central PMC5026656.
  61. Muto, M, Giurazza, F, Silva, RP, Guarnieri, G. Rational approach, technique and selection criteria treating lumbar disk herniations by oxygen-ozone therapy. Interv Neuroradiol. 2016;22 (6):736-740. doi: 10.1177/1591019916659266. PubMed PMID:27485047 PubMed Central PMC5564357.
  62. Murphy, K, Elias, G, Steppan, J, Boxley, C, Balagurunathan, K, Victor, X et al.. Percutaneous Treatment of Herniated Lumbar Discs with Ozone: Investigation of the Mechanisms of Action. J Vasc Interv Radiol. 2016;27 (8):1242-1250.e3. doi: 10.1016/j.jvir.2016.04.012. PubMed PMID:27363296 .
  63. Bonetti, M, Zambello, A, Leonardi, M, Princiotta, C. Herniated disks unchanged over time: Size reduced after oxygen-ozone therapy. Interv Neuroradiol. 2016;22 (4):466-72. doi: 10.1177/1591019916637356. PubMed PMID:27066816 PubMed Central PMC4984384.
  64. Vanni, D, Galzio, R, Kazakova, A, Pantalone, A, Sparvieri, A, Salini, V et al.. Intraforaminal ozone therapy and particular side effects: preliminary results and early warning. Acta Neurochir (Wien). 2016;158 (5):991-3. doi: 10.1007/s00701-016-2755-y. PubMed PMID:26976001 .
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  66. Liu, H, Wang, Y, An, JX, Williams, JP, Cope, DK. Thunderclap Headache Caused by an Inadvertent Epidural Puncture During Oxygen-ozone Therapy for Patient with Cervical Disc Herniation. Chin Med J (Engl). 2016;129 (4):498-9. doi: 10.4103/0366-6999.176080. PubMed PMID:26879031 PubMed Central PMC4800858.
  67. Perri, M, Marsecano, C, Varrassi, M, Giordano, AV, Splendiani, A, di Cesare, E et al.. Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients. Radiol Med. 2016;121 (6):463-71. doi: 10.1007/s11547-015-0598-x. PubMed PMID:26676838 .
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  77. Ren, XC, Wang, XY, Zhang, SH, Yang, ZQ, Wei, XC. [Treatment of lumbar intervertebral disc herniation with coblation combined with ozone nucleus pulposus ablation]. Zhongguo Gu Shang. 2013;26 (10):815-8. . PubMed PMID:24490526 .
  78. Fort, NM, Aichmair, A, Miller, AO, Girardi, FP. L5-S1 Achromobacter xylosoxidans infection secondary to oxygen-ozone therapy for the treatment of lumbosacral disc herniation: a case report and review of the literature. Spine (Phila Pa 1976). 2014;39 (6):E413-6. doi: 10.1097/BRS.0000000000000195. PubMed PMID:24384664 .
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