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Estudios científicos

Estudios clinicos en pacientes con hernia discal tratados con ozono

  1. Barbosa, LT, Rodrigues, CFS, Andrade, RR, Barbosa, FT. The effectiveness of percutaneous injections of ozonotherapy in low back pain. Rev Assoc Med Bras (1992). 2020;66 (8):1146-1151. doi: 10.1590/1806-9282.66.8.1146. PubMed PMID:32935812 .
  2. de Sire, A, Baricich, A, Minetto, MA, Cisari, C, Invernizzi, M. Low back pain related to a sacral insufficiency fracture: role of paravertebral oxygen-ozone therapy in a paradigmatic case of nociplastic pain. Funct. Neurol. ;34 (2):119-122. . PubMed PMID:31556392 .
  3. Chirchiglia, D, Chirchiglia, P, Stroscio, C, Volpentesta, G, Lavano, A. Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain. J Neurol Surg A Cent Eur Neurosurg. 2019;80 (6):503-506. doi: 10.1055/s-0039-1685197. PubMed PMID:31430795 .
  4. Özcan, Ç, Polat, Ö, Çelik, H, Uçar, BY. The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain. Pain Pract. 2019;19 (8):821-825. doi: 10.1111/papr.12812. PubMed PMID:31228871 .
  5. Bhatia, A, Munk, P, Lee, D, Elias, G, Murphy, K. Percutaneous Ozone Treatment for Herniated Lumbar Discs: 1-Year Follow-up of a Multicenter Pilot Study of a Handheld Disposable Ozone-Generating Device. J Vasc Interv Radiol. 2019;30 (5):752-760. doi: 10.1016/j.jvir.2018.09.037. PubMed PMID:30922796 .
  6. Di Mauro, R, Cantarella, G, Bernardini, R, Di Rosa, M, Barbagallo, I, Distefano, A et al.. The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases. Int J Mol Sci. 2019;20 (3):. doi: 10.3390/ijms20030634. PubMed PMID:30717203 PubMed Central PMC6387239.
  7. Wang, J, Wu, M, Lin, X, Li, Y, Fu, Z. Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats. Pain Res Manag. 2018;2018 :5192814. doi: 10.1155/2018/5192814. PubMed PMID:30651902 PubMed Central PMC6311849.
  8. Costa, T, Linhares, D, Ribeiro da Silva, M, Neves, N. Ozone therapy for low back pain. A systematic review. Acta Reumatol Port. ;43 (3):172-181. . PubMed PMID:30414366 .
  9. Seyam, O, Smith, NL, Reid, I, Gandhi, J, Jiang, W, Khan, SA et al.. Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res. ;8 (3):103-110. doi: 10.4103/2045-9912.241075. PubMed PMID:30319765 PubMed Central PMC6178642.
  10. Hosseini, B, Taheri, M, Sheibani, K. Comparing the results of intradiscal ozone injection to treat different types of intervertebral disc herniation based on MSU classification. Interv Neuroradiol. 2019;25 (1):111-116. doi: 10.1177/1591019918800458. PubMed PMID:30227808 PubMed Central PMC6378534.
  11. Ezeldin, M, Leonardi, M, Princiotta, C, Dall'olio, M, Tharwat, M, Zaki, M et al.. Percutaneous ozone nucleolysis for lumbar disc herniation. Neuroradiology. 2018;60 (11):1231-1241. doi: 10.1007/s00234-018-2083-4. PubMed PMID:30206674 PubMed Central PMC6208962.
  12. Beyaz, SG, Sayhan, H. Six-Month Results of Cervical Intradiscal Oxygen-Ozone Mixture Therapy on Patients with Neck Pain: Preliminary Findings. Pain Physician. 2018;21 (4):E449-E456. . PubMed PMID:30045611 .
  13. Ozcan, S, Muz, A, Yildiz Altun, A, Onal, SA. Intradiscal ozone therapy for lumbar disc herniation. Cell. Mol. Biol. (Noisy-le-grand). 2018;64 (5):52-55. . PubMed PMID:29729693 .
  14. Biazzo, A, Corriero, AS, Confalonieri, N. Intramuscular oxygen-ozone therapy in the treatment of low back pain. Acta Biomed. 2018;89 (1):41-46. doi: 10.23750/abm.v89i1.5315. PubMed PMID:29633741 PubMed Central PMC6357609.
  15. Niu, T, Lv, C, Yi, G, Tang, H, Gong, C, Niu, S et al.. Therapeutic Effect of Medical Ozone on Lumbar Disc Herniation. Med. Sci. Monit. 2018;24 :1962-1969. doi: 10.12659/msm.903243. PubMed PMID:29611536 PubMed Central PMC5896688.
  16. Yang, CS, Zhang, LJ, Sun, ZH, Yang, L, Shi, FD. Acute prevertebral abscess secondary to intradiscal oxygen-ozone chemonucleolysis for treatment of a cervical disc herniation. J. Int. Med. Res. 2018;46 (6):2461-2465. doi: 10.1177/0300060518764186. PubMed PMID:29584512 PubMed Central PMC6023037.
  17. Elawamy, A, Kamel, EZ, Hassanien, M, Wahba, OM, Amin, SE. Implication of Two Different Doses of Intradiscal Ozone-Oxygen Injection upon the Pain Alleviation in Patients with Low Back Pain: A Randomized, Single-Blind Study. Pain Physician. 2018;21 (1):E25-E31. . PubMed PMID:29357333 .
  18. Wang, H, Zhou, Y, Jiang, Z. Ozone injection with or without percutaneous microdiscectomy for treatment of cervical disc herniation. Technol Health Care. 2018;26 (2):319-327. doi: 10.3233/THC-170956. PubMed PMID:29332056 .
  19. Ghatge, S, Modi, PD, Modi, DB. Clinical and Radiological Improvement Following Ozone Disc Nucleolysis: A Case Report. Cureus. 2017;9 (4):e1162. doi: 10.7759/cureus.1162. PubMed PMID:28507834 PubMed Central PMC5429154.
  20. Bruno, F, Smaldone, F, Varrassi, M, Arrigoni, F, Barile, A, Di Cesare, E et al.. MRI findings in lumbar spine following O2-O3 chemiodiscolysis: A long-term follow-up. Interv Neuroradiol. 2017;23 (4):444-450. doi: 10.1177/1591019917703784. PubMed PMID:28485657 PubMed Central PMC5684903.
  21. Giurazza, F, Guarnieri, G, Murphy, KJ, Muto, M. Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation. Can Assoc Radiol J. 2017;68 (2):171-177. doi: 10.1016/j.carj.2016.12.007. PubMed PMID:28438284 .
  22. Vaiano, AS, Valente, C, De Benedetti, G, Caramello, G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64 (12):944-946. doi: 10.4103/0301-4738.198858. PubMed PMID:28112142 PubMed Central PMC5322716.
  23. Andrés-Cano, P, Vela, T, Cano, C, García, G, Vera, JC, Andrés-García, JA et al.. Cervical Spondylodiscitis After Oxygen-Ozone Therapy for Treatment of a Cervical Disc Herniation: a Case Report and Review of the Literature. HSS J. 2016;12 (3):278-283. doi: 10.1007/s11420-016-9500-1. PubMed PMID:27703423 PubMed Central PMC5026656.
  24. Muto, M, Giurazza, F, Silva, RP, Guarnieri, G. Rational approach, technique and selection criteria treating lumbar disk herniations by oxygen-ozone therapy. Interv Neuroradiol. 2016;22 (6):736-740. doi: 10.1177/1591019916659266. PubMed PMID:27485047 PubMed Central PMC5564357.
  25. Murphy, K, Elias, G, Steppan, J, Boxley, C, Balagurunathan, K, Victor, X et al.. Percutaneous Treatment of Herniated Lumbar Discs with Ozone: Investigation of the Mechanisms of Action. J Vasc Interv Radiol. 2016;27 (8):1242-1250.e3. doi: 10.1016/j.jvir.2016.04.012. PubMed PMID:27363296 .
  26. Bonetti, M, Zambello, A, Leonardi, M, Princiotta, C. Herniated disks unchanged over time: Size reduced after oxygen-ozone therapy. Interv Neuroradiol. 2016;22 (4):466-72. doi: 10.1177/1591019916637356. PubMed PMID:27066816 PubMed Central PMC4984384.
  27. Vanni, D, Galzio, R, Kazakova, A, Pantalone, A, Sparvieri, A, Salini, V et al.. Intraforaminal ozone therapy and particular side effects: preliminary results and early warning. Acta Neurochir (Wien). 2016;158 (5):991-3. doi: 10.1007/s00701-016-2755-y. PubMed PMID:26976001 .
  28. Baeza-Noci, J. Comments on "Intraforaminal ozone therapy and particular side effects: preliminary results and early warning". Acta Neurochir (Wien). 2016;158 (5):989-90. doi: 10.1007/s00701-016-2754-z. PubMed PMID:26928731 .
  29. Liu, H, Wang, Y, An, JX, Williams, JP, Cope, DK. Thunderclap Headache Caused by an Inadvertent Epidural Puncture During Oxygen-ozone Therapy for Patient with Cervical Disc Herniation. Chin. Med. J. 2016;129 (4):498-9. doi: 10.4103/0366-6999.176080. PubMed PMID:26879031 PubMed Central PMC4800858.
  30. Perri, M, Marsecano, C, Varrassi, M, Giordano, AV, Splendiani, A, di Cesare, E et al.. Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients. Radiol Med. 2016;121 (6):463-71. doi: 10.1007/s11547-015-0598-x. PubMed PMID:26676838 .
  31. Vanni, D, Galzio, R, Kazakova, A, Pantalone, A, Sparvieri, A, Salini, V et al.. Intraforaminal ozone therapy and particular side effects: preliminary results and early warning. Acta Neurochir (Wien). 2016;158 (3):491-6. doi: 10.1007/s00701-015-2545-y. PubMed PMID:26293228 .
  32. Niu, XK, Bhetuwal, A, Yang, HF. Diffusion-Weighted Imaging for Pretreatment Evaluation and Prediction of Treatment Effect in Patients Undergoing CT-Guided Injection for Lumbar Disc Herniation. Korean J Radiol. ;16 (4):874-80. doi: 10.3348/kjr.2015.16.4.874. PubMed PMID:26175588 PubMed Central PMC4499553.
  33. Murphy, K, Muto, M, Steppan, J, Meaders, T, Boxley, C. Treatment of Contained Herniated Lumbar Discs With Ozone and Corticosteroid: A Pilot Clinical Study. Can Assoc Radiol J. 2015;66 (4):377-84. doi: 10.1016/j.carj.2015.01.003. PubMed PMID:26092159 .
  34. Perri, M, Grattacaso, G, Di Tunno, V, Marsecano, C, Di Cesare, E, Splendiani, A et al.. MRI DWI/ADC signal predicts shrinkage of lumbar disc herniation after O2-O3 discolysis. Neuroradiol J. 2015;28 (2):198-204. doi: 10.1177/1971400915576658. PubMed PMID:25923680 PubMed Central PMC4757152.
  35. Perri, M, Grattacaso, G, di Tunno, V, Marsecano, C, Gennarelli, A, Michelini, G et al.. T2 shine-through phenomena in diffusion-weighted MR imaging of lumbar discs after oxygen-ozone discolysis: a randomized, double-blind trial with steroid and O2-O3 discolysis versus steroid only. Radiol Med. 2015;120 (10):941-50. doi: 10.1007/s11547-015-0519-z. PubMed PMID:25743238 .
  36. Dall'Olio, M, Princiotta, C, Cirillo, L, Budai, C, de Santis, F, Bartolini, S et al.. Oxygen-ozone therapy for herniated lumbar disc in patients with subacute partial motor weakness due to nerve root compression. Interv Neuroradiol. 2014;20 (5):547-54. doi: 10.15274/INR-2014-10078. PubMed PMID:25363257 PubMed Central PMC4243224.
  37. Crockett, MT, Moynagh, M, Long, N, Kilcoyne, A, Dicker, P, Synnott, K et al.. Ozone-augmented percutaneous discectomy: a novel treatment option for refractory discogenic sciatica. Clin Radiol. 2014;69 (12):1280-6. doi: 10.1016/j.crad.2014.08.008. PubMed PMID:25240564 .
  38. Li, B, Xu, XX, Du, Y, Yang, HF, Li, Y, Zhang, Q et al.. CT-guided chemonucleolysis combined with psoas compartment block in lumbar disc herniation: a randomized controlled study. Pain Med. 2014;15 (9):1470-6. doi: 10.1111/pme.12491. PubMed PMID:25041326 .
  39. Apuzzo, D, Giotti, C, Pasqualetti, P, Ferrazza, P, Soldati, P, Zucco, GM et al.. An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global postural re-education in complicated chronic low back pain. Funct. Neurol. ;29 (1):31-9. . PubMed PMID:25014047 PubMed Central PMC4172245.
  40. Ren, XC, Wang, XY, Zhang, SH, Yang, ZQ, Wei, XC. [Treatment of lumbar intervertebral disc herniation with coblation combined with ozone nucleus pulposus ablation]. Zhongguo Gu Shang. 2013;26 (10):815-8. . PubMed PMID:24490526 .
  41. Fort, NM, Aichmair, A, Miller, AO, Girardi, FP. L5-S1 Achromobacter xylosoxidans infection secondary to oxygen-ozone therapy for the treatment of lumbosacral disc herniation: a case report and review of the literature. Spine. 2014;39 (6):E413-6. doi: 10.1097/BRS.0000000000000195. PubMed PMID:24384664 .
  42. Zhang, Y, Ma, Y, Jiang, J, Ding, T, Wang, J. Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone. J Back Musculoskelet Rehabil. 2013;26 (3):317-22. doi: 10.3233/BMR-130386. PubMed PMID:23893147 .
  43. Splendiani, A, Perri, M, Conchiglia, A, Fasano, F, Di Egidio, G, Masciocchi, C et al.. MR assessment of lumbar disk herniation treated with oxygen-ozone diskolysis: the role of DWI and related ADC versus intervertebral disk volumetric analysis for detecting treatment response. Neuroradiol J. 2013;26 (3):347-56. doi: 10.1177/197140091302600316. PubMed PMID:23859294 PubMed Central PMC5278852.
  44. Wang, YM, Cai, ZM, Lu, YH. [Medical ozone injection at lumbar Jiaji (EX-B2) points for 100 cases of lumbar vertebrae disc]. Zhongguo Zhen Jiu. 2012;32 (10):939-40. . PubMed PMID:23259280 .
  45. Zhang, YC, Xu, YY, Yang, SE, Bao, SQ, Zhang, L. [Lumbar disc herniation treated with Shu-needle therapy and ozone injection of low concentration]. Zhongguo Zhen Jiu. 2012;32 (9):829-32. . PubMed PMID:23227695 .
  46. Rahimi-Movaghar, V, Eslami, V. The major efficient mechanisms of ozone therapy are obtained in intradiscal procedures. Pain Physician. ;15 (6):E1007-8. . PubMed PMID:23159972 .
  47. Melchionda, D, Milillo, P, Manente, G, Stoppino, L, Macarini, L. Treatment of radiculopathies: a study of efficacy and tollerability of paravertebral oxygen-ozone injections compared with pharmacological anti-inflammatory treatment. J. Biol. Regul. Homeost. Agents. ;26 (3):467-74. . PubMed PMID:23034266 .
  48. Lehnert, T, Naguib, NN, Wutzler, S, Nour-Eldin, NE, Bauer, RW, Kerl, JM et al.. Analysis of disk volume before and after CT-guided intradiscal and periganglionic ozone-oxygen injection for the treatment of lumbar disk herniation. J Vasc Interv Radiol. 2012;23 (11):1430-6. doi: 10.1016/j.jvir.2012.07.029. PubMed PMID:22999458 .
  49. Stagni, S, de Santis, F, Cirillo, L, Dall'olio, M, Princiotta, C, Simonetti, L et al.. A minimally invasive treatment for lumbar disc herniation: DiscoGel® chemonucleolysis in patients unresponsive to chemonucleolysis with oxygen-ozone. Interv Neuroradiol. 2012;18 (1):97-104. doi: 10.1177/159101991201800113. PubMed PMID:22440607 PubMed Central PMC3312096.
  50. Magalhaes, FN, Dotta, L, Sasse, A, Teixera, MJ, Fonoff, ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. ;15 (2):E115-29. . PubMed PMID:22430658 .
  51. Bocci, V, Zanardi, I, Borrelli, E, Travagli, V. Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation. J. Pharm. Pharmacol. 2012;64 (4):482-9. doi: 10.1111/j.2042-7158.2011.01427.x. PubMed PMID:22420654 .
  52. Yu, Z, Luo, W, Wang, B. [Targeted injection of ozone through the posterior approach via the spinal canal and dural sac for treating lumbar disc herniation]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32 (2):243-6. . PubMed PMID:22381768 .
  53. León Fernández, OS, Pantoja, M, Díaz Soto, MT, Dranguet, J, García Insua, M, Viebhan-Hánsler, R et al.. Ozone oxidative post-conditioning reduces oxidative protein damage in patients with disc hernia. Neurol. Res. 2012;34 (1):59-67. doi: 10.1179/1743132811Y.0000000060. PubMed PMID:22196863 .
  54. Lu, W, Li, YH, He, XF. Treatment of large lumbar disc herniation with percutaneous ozone injection via the posterior-lateral route and inner margin of the facet joint. World J Radiol. 2010;2 (3):109-12. doi: 10.4329/wjr.v2.i3.109. PubMed PMID:21160944 PubMed Central PMC2998940.
  55. Qu, QW, Zhu, SM, Zheng, JB, Liu, XJ, Wang, MC, Xue, XY et al.. [Electrophysiologial evaluation of ozone in treating of lumbar disc herniation with curving sheath-needle multi-direction rotating injection]. Zhongguo Gu Shang. 2010;23 (10):765-8. . PubMed PMID:21137291 .
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Hola, soy Katty del área de INFORMES, en que puedo ayudarte?
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