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Unidad de Terapia Regenerativa Tisular – Centro Medico Clinica Alemana

Estudios científicos

  1. DesRochers, J, DesRochers, R, Patel, D, Andruszka, C, Manchanda, S, Ernazarov, A et al.. Mesenchymal stem cells and thermal annular procedures for discogenic pain: a systematic review with pooled analysis. Pain Manag. 2024;14 (2):101-114. doi: 10.2217/pmt-2023-0107. PubMed PMID:38275178 .
  2. Mizuno, S, Vadala, G, Kang, JD. Biological Therapeutic Modalities for Intervertebral Disc Diseases: An Orthoregeneration Network (ON) Foundation Review. Arthroscopy. 2024;40 (3):1019-1030. doi: 10.1016/j.arthro.2023.10.032. PubMed PMID:37918699 .
  3. Grangeat, AM, Erario, MLA. The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment. Int J Mol Sci. 2023;24 (7):. doi: 10.3390/ijms24076538. PubMed PMID:37047511 PubMed Central PMC10095297.
  4. Lewandrowski, KU, Dowling, A, Vera, JC, Leon, JFR, Telfeian, AE, Lorio, MP et al.. Pain Relief After Allogenic Stem Cell Disc Therapy. Pain Physician. 2023;26 (2):197-206. . PubMed PMID:36988365 .
  5. Sudo, H, Miyakoshi, T, Watanabe, Y, Ito, YM, Kahata, K, Tha, KK et al.. Protocol for treating lumbar spinal canal stenosis with a combination of ultrapurified, allogenic bone marrow-derived mesenchymal stem cells and in situ-forming gel: a multicentre, prospective, double-blind randomised controlled trial. BMJ Open. 2023;13 (2):e065476. doi: 10.1136/bmjopen-2022-065476. PubMed PMID:36731929 PubMed Central PMC9896178.
  6. Li, X, Shen, X, Wang, Z, Jiang, H, Ma, Z, Yu, P et al.. Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation. Front Pharmacol. 2022;13 :892594. doi: 10.3389/fphar.2022.892594. PubMed PMID:36506585 PubMed Central PMC9732013.
  7. Penolazzi, L, Lambertini, E, D'Agostino, S, Pozzobon, M, Notarangelo, MP, Greco, P et al.. Decellularized extracellular matrix-based scaffold and hypoxic priming: A promising combination to improve the phenotype of degenerate intervertebral disc cells. Life Sci. 2022;301 :120623. doi: 10.1016/j.lfs.2022.120623. PubMed PMID:35537547 .
  8. Xin, J, Wang, Y, Zheng, Z, Wang, S, Na, S, Zhang, S et al.. Treatment of Intervertebral Disc Degeneration. Orthop Surg. 2022;14 (7):1271-1280. doi: 10.1111/os.13254. PubMed PMID:35486489 PubMed Central PMC9251272.
  9. Xuan, A, Ruan, D, Wang, C, He, Q, Wang, D, Hou, L et al.. Intradiscal Injection of Autologous Discogenic Cells in Patients with Discectomy: A Prospective Clinical Study of Its Safety and Feasibility. Stem Cells Transl Med. 2022;11 (5):490-503. doi: 10.1093/stcltm/szac013. PubMed PMID:35427416 PubMed Central PMC9154349.
  10. Seki, S, Iwasaki, M, Makino, H, Yahara, Y, Miyazaki, Y, Kamei, K et al.. Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture. Int J Mol Sci. 2022;23 (7):. doi: 10.3390/ijms23074059. PubMed PMID:35409417 PubMed Central PMC8999916.
  11. Sakai, D, Schol, J, Watanabe, M. Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease. Medicina (Kaunas). 2022;58 (2):. doi: 10.3390/medicina58020267. PubMed PMID:35208590 PubMed Central PMC8878570.
  12. Widjaja, G, Jalil, AT, Budi, HS, Abdelbasset, WK, Efendi, S, Suksatan, W et al.. Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier. Int Immunopharmacol. 2022;105 :108537. doi: 10.1016/j.intimp.2022.108537. PubMed PMID:35101851 .
  13. Schneider, BJ, Hunt, C, Conger, A, Qu, W, Maus, TP, Vorobeychik, Y et al.. The effectiveness of intradiscal biologic treatments for discogenic low back pain: a systematic review. Spine J. 2022;22 (2):226-237. doi: 10.1016/j.spinee.2021.07.015. PubMed PMID:34352363 .
  14. Xu, B, Zhang, H, Du, L, Yuan, Q, Zhang, K, Xu, H et al.. Selective Retention of Bone Marrow Stromal Cells with Gelatin Sponge for Repair of Intervertebral Disc Defects after Microendoscopic Discectomy: A Prospective Controlled Study and 2-Year Follow-Up. Biomed Res Int. 2021;2021 :4822383. doi: 10.1155/2021/4822383. PubMed PMID:34337012 PubMed Central PMC8294975.
  15. Sako, K, Sakai, D, Nakamura, Y, Schol, J, Matsushita, E, Warita, T et al.. Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells. Int J Mol Sci. 2021;22 (9):. doi: 10.3390/ijms22094723. PubMed PMID:33946902 PubMed Central PMC8124367.
  16. Xiang, H, Su, W, Wu, X, Chen, W, Cong, W, Yang, S et al.. Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress. Oxid Med Cell Longev. 2020;2020 :6697577. doi: 10.1155/2020/6697577. PubMed PMID:33488928 PubMed Central PMC7787770.
  17. Luo, L, Jian, X, Sun, H, Qin, J, Wang, Y, Zhang, J et al.. Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy. Stem Cells. 2021;39 (4):467-481. doi: 10.1002/stem.3322. PubMed PMID:33459443 PubMed Central PMC8048856.
  18. Mujawar, S, Iyengar, K, Nadkarni, S, Mulherkar, R. Expansion and characterization of cells from surgically removed intervertebral disc fragments in xenogen-free medium. J Biosci. 2020;45 :. . PubMed PMID:32975235 .
  19. Wu, PH, Kim, HS, Jang, IT. Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease. Int J Mol Sci. 2020;21 (6):. doi: 10.3390/ijms21062135. PubMed PMID:32244936 PubMed Central PMC7139690.
  20. Ukeba, D, Sudo, H, Tsujimoto, T, Ura, K, Yamada, K, Iwasaki, N et al.. Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs. EBioMedicine. 2020;53 :102698. doi: 10.1016/j.ebiom.2020.102698. PubMed PMID:32143180 PubMed Central PMC7057222.
  21. Che, H, Li, J, Li, Y, Ma, C, Liu, H, Qin, J et al.. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. Elife. 2020;9 :. doi: 10.7554/eLife.52570. PubMed PMID:32125276 PubMed Central PMC7065909.
  22. Takeoka, Y, Yurube, T, Morimoto, K, Kunii, S, Kanda, Y, Tsujimoto, R et al.. Reduced nucleotomy-induced intervertebral disc disruption through spontaneous spheroid formation by the Low Adhesive Scaffold Collagen (LASCol). Biomaterials. 2020;235 :119781. doi: 10.1016/j.biomaterials.2020.119781. PubMed PMID:31981764 .
  23. Law, L, Hunt, CL, van Wijnen, AJ, Nassr, A, Larson, AN, Eldrige, JS et al.. Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies. Pain Med. 2019;20 (8):1570-1583. doi: 10.1093/pm/pny256. PubMed PMID:30597057 .
  24. Steffen, F, Bertolo, A, Affentranger, R, Ferguson, SJ, Stoyanov, J. Treatment of Naturally Degenerated Canine Lumbosacral Intervertebral Discs with Autologous Mesenchymal Stromal Cells and Collagen Microcarriers: A Prospective Clinical Study. Cell Transplant. 2019;28 (2):201-211. doi: 10.1177/0963689718815459. PubMed PMID:30488736 PubMed Central PMC6362527.
  25. Migliorini, F, Rath, B, Tingart, M, Baroncini, A, Quack, V, Eschweiler, J et al.. Autogenic mesenchymal stem cells for intervertebral disc regeneration. Int Orthop. 2019;43 (4):1027-1036. doi: 10.1007/s00264-018-4218-y. PubMed PMID:30415465 .
  26. Pizzute, T, He, F, Zhang, XB, Pei, M. Impact of Wnt signals on human intervertebral disc cell regeneration. J Orthop Res. 2018;36 (12):3196-3207. doi: 10.1002/jor.24115. PubMed PMID:30035326 PubMed Central PMC7261601.
  27. Bari, E, Perteghella, S, Marrubini, G, Sorrenti, M, Catenacci, L, Tripodo, G et al.. In vitro efficacy of silk sericin microparticles and platelet lysate for intervertebral disk regeneration. Int J Biol Macromol. 2018;118 (Pt A):792-799. doi: 10.1016/j.ijbiomac.2018.06.135. PubMed PMID:29959012 .
  28. Huang, X, Wang, W, Liu, X, Xi, Y, Yu, J, Yang, X et al.. Bone mesenchymal stem cells attenuate radicular pain by inhibiting microglial activation in a rat noncompressive disk herniation model. Cell Tissue Res. 2018;374 (1):99-110. doi: 10.1007/s00441-018-2855-5. PubMed PMID:29858667 .
  29. Serakinci, N, Savtekin, G. Modeling Mesenchymal Stem Cells in TMJ Rheumatoid Arthritis and Osteoarthritis Therapy. Crit Rev Eukaryot Gene Expr. 2017;27 (3):205-210. doi: 10.1615/CritRevEukaryotGeneExpr.2017019380. PubMed PMID:29199605 .
  30. Miguélez-Rivera, L, Pérez-Castrillo, S, González-Fernández, ML, Prieto-Fernández, JG, López-González, ME, García-Cosamalón, J et al.. Immunomodulation of mesenchymal stem cells in discogenic pain. Spine J. 2018;18 (2):330-342. doi: 10.1016/j.spinee.2017.09.002. PubMed PMID:28939169 .
  31. Knezevic, NN, Mandalia, S, Raasch, J, Knezevic, I, Candido, KD. Treatment of chronic low back pain - new approaches on the horizon. J Pain Res. 2017;10 :1111-1123. doi: 10.2147/JPR.S132769. PubMed PMID:28546769 PubMed Central PMC5436786.
  32. Steffen, F, Smolders, LA, Roentgen, AM, Bertolo, A, Stoyanov, J. Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety, and Preliminary Results. Tissue Eng Part C Methods. 2017;23 (11):643-651. doi: 10.1089/ten.TEC.2017.0033. PubMed PMID:28471303 .
  33. Hur, JW, Bae, T, Ye, S, Kim, JH, Lee, S, Kim, K et al.. Myofibroblast in the ligamentum flavum hypertrophic activity. Eur Spine J. 2017;26 (8):2021-2030. doi: 10.1007/s00586-017-4981-2. PubMed PMID:28180980 .
  34. Kim, Y, Lee, SH, Kim, WH, Kweon, OK. Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs. J Vet Sci. 2016;17 (1):123-6. doi: 10.4142/jvs.2016.17.1.123. PubMed PMID:27051350 PubMed Central PMC4808638.
  35. Wu, T, Song, HX, Dong, Y, Li, JH. Cell-Based Therapies for Lumbar Discogenic Low Back Pain: Systematic Review and Single-Arm Meta-analysis. Spine (Phila Pa 1976). 2018;43 (1):49-57. doi: 10.1097/BRS.0000000000001549. PubMed PMID:26953666 .
  36. Shang, J, Fan, X, Shangguan, L, Liu, H, Zhou, Y. Global Gene Expression Profiling and Alternative Splicing Events during the Chondrogenic Differentiation of Human Cartilage Endplate-Derived Stem Cells. Biomed Res Int. 2015;2015 :604972. doi: 10.1155/2015/604972. PubMed PMID:26649308 PubMed Central PMC4662983.
  37. Liu, K, Chen, Z, Luo, XW, Song, GQ, Wang, P, Li, XD et al.. Determination of the potential of induced pluripotent stem cells to differentiate into mouse nucleus pulposus cells in vitro. Genet Mol Res. 2015;14 (4):12394-405. doi: 10.4238/2015.October.16.6. PubMed PMID:26505389 .
  38. Besalti, O, Can, P, Akpinar, E, Aktas, Z, Elcin, AE, Elcin, YM et al.. Intraspinal Transplantation of Autologous Neurogenically-Induced Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Paraplegic Dogs without Deep Pain Perception Secondary to Intervertebral Disk Disease. Turk Neurosurg. 2015;25 (4):625-32. doi: 10.5137/1019-5149.JTN.14502-15.2. PubMed PMID:26242341 .
  39. Li, Z, Peroglio, M, Alini, M, Grad, S. Potential and limitations of intervertebral disc endogenous repair. Curr Stem Cell Res Ther. 2015;10 (4):329-38. doi: 10.2174/1574888x10666150305105114. PubMed PMID:25741710 .
  40. Marfia, G, Navone, SE, Di Vito, C, Tabano, S, Giammattei, L, Di Cristofori, A et al.. Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin. Stem Cells Dev. 2015;24 (3):320-8. doi: 10.1089/scd.2014.0282. PubMed PMID:25203751 .
  41. Kadow, T, Sowa, G, Vo, N, Kang, JD. Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?. Clin Orthop Relat Res. 2015;473 (6):1903-12. doi: 10.1007/s11999-014-3774-8. PubMed PMID:25024024 PubMed Central PMC4418989.
  42. Zhang, Z, Li, F, Tian, H, Guan, K, Zhao, G, Shan, J et al.. Differentiation of adipose-derived stem cells toward nucleus pulposus-like cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro. Chin Med J (Engl). 2014;127 (2):314-21. . PubMed PMID:24438622 .
  43. Chon, BH, Lee, EJ, Jing, L, Setton, LA, Chen, J. Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system. Stem Cell Res Ther. 2013;4 (5):120. doi: 10.1186/scrt331. PubMed PMID:24405888 PubMed Central PMC3854685.
  44. Gilbert, HT, Hoyland, JA, Richardson, SM. Stem cell regeneration of degenerated intervertebral discs: current status (update). Curr Pain Headache Rep. 2013;17 (12):377. doi: 10.1007/s11916-013-0377-0. PubMed PMID:24234817 .
  45. Jung, JW, Kwon, M, Choi, JC, Shin, JW, Park, IW, Choi, BW et al.. Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy. Yonsei Med J. 2013;54 (5):1293-6. doi: 10.3349/ymj.2013.54.5.1293. PubMed PMID:23918585 PubMed Central PMC3743204.
  46. Anderson, DG, Markova, D, An, HS, Chee, A, Enomoto-Iwamoto, M, Markov, V et al.. Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. Am J Phys Med Rehabil. 2013;92 (5):420-9. doi: 10.1097/PHM.0b013e31825f148a. PubMed PMID:23598901 PubMed Central PMC4238943.
  47. Salvatierra, JC, Yuan, TY, Fernando, H, Castillo, A, Gu, WY, Cheung, HS et al.. Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc. Cell Mol Bioeng. 2011;4 (2):302-310. doi: 10.1007/s12195-011-0164-0. PubMed PMID:21625336 PubMed Central PMC3103069.
  48. Loreto, C, Musumeci, G, Castorina, A, Loreto, C, Martinez, G. Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death. Ann Anat. 2011;193 (2):156-62. doi: 10.1016/j.aanat.2010.12.001. PubMed PMID:21330123 .
  49. Feng, G, Zhao, X, Liu, H, Zhang, H, Chen, X, Shi, R et al.. Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration. J Neurosurg Spine. 2011;14 (3):322-9. doi: 10.3171/2010.11.SPINE10285. PubMed PMID:21250814 .
  50. Nerurkar, NL, Sen, S, Huang, AH, Elliott, DM, Mauck, RL. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine (Phila Pa 1976). 2010;35 (8):867-73. doi: 10.1097/BRS.0b013e3181d74414. PubMed PMID:20354467 PubMed Central PMC3421837.
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  52. Guehring, T, Nerlich, A, Kroeber, M, Richter, W, Omlor, GW. Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study. Eur Spine J. 2010;19 (1):113-21. doi: 10.1007/s00586-009-1217-0. PubMed PMID:19936803 PubMed Central PMC2899741.
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Centro Médico Clínica Alemana
Unidad de Terapia Celular
Unidad de Flebología y Linfología
Unidad de Tratamiento del Cáncer

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