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Estudios científicos

  1. Ukeba, D, Sudo, H, Tsujimoto, T, Ura, K, Yamada, K, Iwasaki, N et al.. Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs. EBioMedicine. 2020;53 :102698. doi: 10.1016/j.ebiom.2020.102698. PubMed PMID:32143180 PubMed Central PMC7057222.
  2. Law, L, Hunt, CL, van Wijnen, AJ, Nassr, A, Larson, AN, Eldrige, JS et al.. Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies. Pain Med. 2019;20 (8):1570-1583. doi: 10.1093/pm/pny256. PubMed PMID:30597057 .
  3. Steffen, F, Bertolo, A, Affentranger, R, Ferguson, SJ, Stoyanov, J. Treatment of Naturally Degenerated Canine Lumbosacral Intervertebral Discs with Autologous Mesenchymal Stromal Cells and Collagen Microcarriers: A Prospective Clinical Study. Cell Transplant. 2019;28 (2):201-211. doi: 10.1177/0963689718815459. PubMed PMID:30488736 PubMed Central PMC6362527.
  4. Migliorini, F, Rath, B, Tingart, M, Baroncini, A, Quack, V, Eschweiler, J et al.. Autogenic mesenchymal stem cells for intervertebral disc regeneration. Int Orthop. 2019;43 (4):1027-1036. doi: 10.1007/s00264-018-4218-y. PubMed PMID:30415465 .
  5. Pizzute, T, He, F, Zhang, XB, Pei, M. Impact of Wnt signals on human intervertebral disc cell regeneration. J. Orthop. Res. 2018;36 (12):3196-3207. doi: 10.1002/jor.24115. PubMed PMID:30035326 PubMed Central PMC7261601.
  6. Bari, E, Perteghella, S, Marrubini, G, Sorrenti, M, Catenacci, L, Tripodo, G et al.. In vitro efficacy of silk sericin microparticles and platelet lysate for intervertebral disk regeneration. Int. J. Biol. Macromol. 2018;118 (Pt A):792-799. doi: 10.1016/j.ijbiomac.2018.06.135. PubMed PMID:29959012 .
  7. Huang, X, Wang, W, Liu, X, Xi, Y, Yu, J, Yang, X et al.. Bone mesenchymal stem cells attenuate radicular pain by inhibiting microglial activation in a rat noncompressive disk herniation model. Cell Tissue Res. 2018;374 (1):99-110. doi: 10.1007/s00441-018-2855-5. PubMed PMID:29858667 .
  8. Serakinci, N, Savtekin, G. Modeling Mesenchymal Stem Cells in TMJ Rheumatoid Arthritis and Osteoarthritis Therapy. Crit. Rev. Eukaryot. Gene Expr. 2017;27 (3):205-210. doi: 10.1615/CritRevEukaryotGeneExpr.2017019380. PubMed PMID:29199605 .
  9. Miguélez-Rivera, L, Pérez-Castrillo, S, González-Fernández, ML, Prieto-Fernández, JG, López-González, ME, García-Cosamalón, J et al.. Immunomodulation of mesenchymal stem cells in discogenic pain. Spine J. 2018;18 (2):330-342. doi: 10.1016/j.spinee.2017.09.002. PubMed PMID:28939169 .
  10. Knezevic, NN, Mandalia, S, Raasch, J, Knezevic, I, Candido, KD. Treatment of chronic low back pain - new approaches on the horizon. J Pain Res. 2017;10 :1111-1123. doi: 10.2147/JPR.S132769. PubMed PMID:28546769 PubMed Central PMC5436786.
  11. Steffen, F, Smolders, LA, Roentgen, AM, Bertolo, A, Stoyanov, J. Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety, and Preliminary Results. Tissue Eng Part C Methods. 2017;23 (11):643-651. doi: 10.1089/ten.TEC.2017.0033. PubMed PMID:28471303 .
  12. Hur, JW, Bae, T, Ye, S, Kim, JH, Lee, S, Kim, K et al.. Myofibroblast in the ligamentum flavum hypertrophic activity. Eur Spine J. 2017;26 (8):2021-2030. doi: 10.1007/s00586-017-4981-2. PubMed PMID:28180980 .
  13. Kim, Y, Lee, SH, Kim, WH, Kweon, OK. Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs. J. Vet. Sci. 2016;17 (1):123-6. doi: 10.4142/jvs.2016.17.1.123. PubMed PMID:27051350 PubMed Central PMC4808638.
  14. Wu, T, Song, HX, Dong, Y, Li, JH. Cell-Based Therapies for Lumbar Discogenic Low Back Pain: Systematic Review and Single-Arm Meta-analysis. Spine. 2018;43 (1):49-57. doi: 10.1097/BRS.0000000000001549. PubMed PMID:26953666 .
  15. Shang, J, Fan, X, Shangguan, L, Liu, H, Zhou, Y. Global Gene Expression Profiling and Alternative Splicing Events during the Chondrogenic Differentiation of Human Cartilage Endplate-Derived Stem Cells. Biomed Res Int. 2015;2015 :604972. doi: 10.1155/2015/604972. PubMed PMID:26649308 PubMed Central PMC4662983.
  16. Liu, K, Chen, Z, Luo, XW, Song, GQ, Wang, P, Li, XD et al.. Determination of the potential of induced pluripotent stem cells to differentiate into mouse nucleus pulposus cells in vitro. Genet. Mol. Res. 2015;14 (4):12394-405. doi: 10.4238/2015.October.16.6. PubMed PMID:26505389 .
  17. Besalti, O, Can, P, Akpinar, E, Aktas, Z, Elcin, AE, Elcin, YM et al.. Intraspinal Transplantation of Autologous Neurogenically-Induced Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Paraplegic Dogs without Deep Pain Perception Secondary to Intervertebral Disk Disease. Turk Neurosurg. 2015;25 (4):625-32. doi: 10.5137/1019-5149.JTN.14502-15.2. PubMed PMID:26242341 .
  18. Li, Z, Peroglio, M, Alini, M, Grad, S. Potential and limitations of intervertebral disc endogenous repair. Curr Stem Cell Res Ther. 2015;10 (4):329-38. doi: 10.2174/1574888x10666150305105114. PubMed PMID:25741710 .
  19. Marfia, G, Navone, SE, Di Vito, C, Tabano, S, Giammattei, L, Di Cristofori, A et al.. Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin. Stem Cells Dev. 2015;24 (3):320-8. doi: 10.1089/scd.2014.0282. PubMed PMID:25203751 .
  20. Kadow, T, Sowa, G, Vo, N, Kang, JD. Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?. Clin. Orthop. Relat. Res. 2015;473 (6):1903-12. doi: 10.1007/s11999-014-3774-8. PubMed PMID:25024024 PubMed Central PMC4418989.
  21. Zhang, Z, Li, F, Tian, H, Guan, K, Zhao, G, Shan, J et al.. Differentiation of adipose-derived stem cells toward nucleus pulposus-like cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro. Chin. Med. J. 2014;127 (2):314-21. . PubMed PMID:24438622 .
  22. Chon, BH, Lee, EJ, Jing, L, Setton, LA, Chen, J. Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system. Stem Cell Res Ther. 2013;4 (5):120. doi: 10.1186/scrt331. PubMed PMID:24405888 PubMed Central PMC3854685.
  23. Gilbert, HT, Hoyland, JA, Richardson, SM. Stem cell regeneration of degenerated intervertebral discs: current status (update). Curr Pain Headache Rep. 2013;17 (12):377. doi: 10.1007/s11916-013-0377-0. PubMed PMID:24234817 .
  24. Jung, JW, Kwon, M, Choi, JC, Shin, JW, Park, IW, Choi, BW et al.. Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy. Yonsei Med. J. 2013;54 (5):1293-6. doi: 10.3349/ymj.2013.54.5.1293. PubMed PMID:23918585 PubMed Central PMC3743204.
  25. Anderson, DG, Markova, D, An, HS, Chee, A, Enomoto-Iwamoto, M, Markov, V et al.. Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. Am J Phys Med Rehabil. 2013;92 (5):420-9. doi: 10.1097/PHM.0b013e31825f148a. PubMed PMID:23598901 PubMed Central PMC4238943.
  26. Salvatierra, JC, Yuan, TY, Fernando, H, Castillo, A, Gu, WY, Cheung, HS et al.. Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc. Cell Mol Bioeng. 2011;4 (2):302-310. doi: 10.1007/s12195-011-0164-0. PubMed PMID:21625336 PubMed Central PMC3103069.
  27. Loreto, C, Musumeci, G, Castorina, A, Loreto, C, Martinez, G. Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death. Ann. Anat. 2011;193 (2):156-62. doi: 10.1016/j.aanat.2010.12.001. PubMed PMID:21330123 .
  28. Feng, G, Zhao, X, Liu, H, Zhang, H, Chen, X, Shi, R et al.. Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration. J Neurosurg Spine. 2011;14 (3):322-9. doi: 10.3171/2010.11.SPINE10285. PubMed PMID:21250814 .
  29. Nerurkar, NL, Sen, S, Huang, AH, Elliott, DM, Mauck, RL. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine. 2010;35 (8):867-73. doi: 10.1097/BRS.0b013e3181d74414. PubMed PMID:20354467 PubMed Central PMC3421837.
  30. Gruber, HE, Chow, Y, Hoelscher, GL, Ingram, JA, Zinchenko, N, Norton, HJ et al.. Micromass culture of human anulus cells: morphology and extracellular matrix production. Spine. 2010;35 (10):1033-8. doi: 10.1097/BRS.0b013e3181bc3e04. PubMed PMID:20139802 .
  31. Guehring, T, Nerlich, A, Kroeber, M, Richter, W, Omlor, GW. Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study. Eur Spine J. 2010;19 (1):113-21. doi: 10.1007/s00586-009-1217-0. PubMed PMID:19936803 PubMed Central PMC2899741.
  32. Chen, WH, Liu, HY, Lo, WC, Wu, SC, Chi, CH, Chang, HY et al.. Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma. Biomaterials. 2009;30 (29):5523-33. doi: 10.1016/j.biomaterials.2009.07.019. PubMed PMID:19646749 .
  33. Fassett, DR, Kurd, MF, Vaccaro, AR. Biologic solutions for degenerative disk disease. J Spinal Disord Tech. 2009;22 (4):297-308. doi: 10.1097/BSD.0b013e31816d5f64. PubMed PMID:19494751 .
  34. Mackiewicz, Z, Salo, J, Konttinen, YT, Kaigle Holm, A, Indahl, A, Pajarinen, J et al.. Receptor activator of nuclear factor kappa B ligand in an experimental intervertebral disc degeneration. Clin. Exp. Rheumatol. ;27 (2):299-306. . PubMed PMID:19473572 .
  35. Chen, S, Emery, SE, Pei, M. Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration. Spine. 2009;34 (12):1272-80. doi: 10.1097/BRS.0b013e3181a2b347. PubMed PMID:19455002 .
  36. Henriksson, HB, Svanvik, T, Jonsson, M, Hagman, M, Horn, M, Lindahl, A et al.. Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine. 2009;34 (2):141-8. doi: 10.1097/BRS.0b013e31818f8c20. PubMed PMID:19112334 .
  37. Sakai, D. Future perspectives of cell-based therapy for intervertebral disc disease. Eur Spine J. 2008;17 Suppl 4 :452-8. doi: 10.1007/s00586-008-0743-5. PubMed PMID:19005704 PubMed Central PMC2587661.
  38. Bron, JL, Koenderink, GH, Everts, V, Smit, TH. Rheological characterization of the nucleus pulposus and dense collagen scaffolds intended for functional replacement. J. Orthop. Res. 2009;27 (5):620-6. doi: 10.1002/jor.20789. PubMed PMID:18991343 .
  39. Kuh, SU, Zhu, Y, Li, J, Tsai, KJ, Fei, Q, Hutton, WC et al.. Can TGF-beta1 and rhBMP-2 act in synergy to transform bone marrow stem cells to discogenic-type cells?. Acta Neurochir (Wien). 2008;150 (10):1073-9; discussion 1079. doi: 10.1007/s00701-008-0029-z. PubMed PMID:18781274 .
  40. Saldanha, KJ, Piper, SL, Ainslie, KM, Kim, HT, Majumdar, S. Magnetic resonance imaging of iron oxide labelled stem cells: applications to tissue engineering based regeneration of the intervertebral disc. Eur Cell Mater. 2008;16 :17-25. doi: 10.22203/ecm.v016a03. PubMed PMID:18677684 .
  41. Jandial, R, Aryan, HE, Park, J, Taylor, WT, Snyder, EY. Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge. Neurosurg Focus. 2008;24 (3-4):E21. doi: 10.3171/FOC/2008/24/3-4/E20. PubMed PMID:18341398 .
  42. Sobajima, S, Vadala, G, Shimer, A, Kim, JS, Gilbertson, LG, Kang, JD et al.. Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J. ;8 (6):888-96. doi: 10.1016/j.spinee.2007.09.011. PubMed PMID:18082460 .
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  45. Revell, PA, Damien, E, Di Silvio, L, Gurav, N, Longinotti, C, Ambrosio, L et al.. Tissue engineered intervertebral disc repair in the pig using injectable polymers. J Mater Sci Mater Med. 2007;18 (2):303-8. doi: 10.1007/s10856-006-0693-6. PubMed PMID:17323162 .
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  48. Haufe, SM, Mork, AR. Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs. Stem Cells Dev. 2006;15 (1):136-7. doi: 10.1089/scd.2006.15.136. PubMed PMID:16522171 .
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